Phosphorus tribromide → HCID 136146128, compound

Participants

Reaction Conditions

Reaction Steps

To 1-{3-[7-(6-Methoxy-pyridin-3-yl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-3-(2,2,2-trifluoro-ethyl)-urea (0.187 g, 0.226 mmol) in DCE (10 ml) was added PBr3 (0.174 ml). The reaction was heated at 80° C. for 3 hours, then partitioned between EtOAc and water, insoluble material filtered off and dried to give 1-{3-[7-(6-Oxo-1,6-dihydro-pyridin-3-yl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-3-(2,2,2-trifluoro-ethyl)-urea (0.12 g) MS: [M+H]+428

Provenance & Evidence