Sodium Iodide → HCID 68595616, compound

Participants

Reaction Conditions

Reaction Steps

To 1-{3-[7-(6-Oxo-1,6-dihydro-pyridin-3-yl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-3-(2,2,2-trifluoro-ethyl)-urea (0.12 g, 0.63 mmol) in DMF (1.5 ml) was added N-(3-chloropropyl)piperidine hydrochloride (0.125 g, 0.63 mmol), Cs2CO3 (0.32 g, 0.98 mmol) and NaI (0.095 g, 0.63 mmol). The reaction was heated at 80° C. for 48 hours then partitioned between EtOAc and water, the organic layer was washed with brine, dried (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by preparative HPLC to give the title compound (16 mg) MS: [M+H]+553

Provenance & Evidence