Ethyl isocyanate → HCID 59320850, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of EtNCO (1.6 ml, 20 mmol) and 5-bromo-pyridin-3-ylamine (1.73 g, 10 mmol) in DME (10 ml) was stirred and heated at 60° C. under N2. After 2 hours another aliquot of EtNCO (1.6 ml, 20 mmol) was added and the mixture was stirred at 60° C. for a further 16 hours. After cooling to RT the mixture was evaporated. The residue was triturated with EtOAc. The solid was collected by filtration and dried under vacuum to give the title compound (2.2 g) as a colourless solid. 1H NMR (400 MHz, DMSO-d6): 8.85 (1H, s), 8.43 (1H, d), 8.27 (1H, t), 8.21 (1H, d), 6.39 (1H, t), 3.19-3.05 (2H, m), 1.06 (3H, t).

Provenance & Evidence