Methyl morpholine oxide → HCID 57497682, compound

Participants

Reaction Steps

To a solution of 1-[3-(7-Hydroxymethyl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea (1.42 g, 3.90 mmol) and NMO (1.38, 11.7 mmol) in CH2Cl2 (30 ml) with sieves (3 g) at 0° C. was added TPAP (0.14 g, 0.38 mmol). The reaction mixture was allowed to warm to room temperature and stirred for 18 h, before being filtered to remove the sieves. The organic layer was washed with H2O (×2), dried (MgSO4) and the solvent removed in vacuo. The residue was purified by silica column chromatography (0-60% MeOH in Et2O) to afford the product (0.2 g). MS: [M+H]+=363

Provenance & Evidence