Ammonium Chloride → HCID 59320820, compound

Participants

Reaction Conditions

Reaction Steps

1-[3-(7-Cyano-imidazo[1,2-a]pyridin-3-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea (65 mg, 0.18 mmol), sodium azide (14 mg, 0.19 mmol) and ammonium chloride (11 mg, 0.20 mmol) were dissolved in DMF (2 ml) and heated at 90° C. for 18 h. The reaction mixture was cooled, the solvent removed in vacuo and the crude reaction mixture purified using reverse phase HPLC. This afforded the title compound as a white solid (14 mg). MS: [M+H]+ 403.

Provenance & Evidence