Methyl iodide → HCID 68595843, compound

Participants

Reaction Steps

To a solution of 1-{3-[7-(5-Mercapto-4-methyl-4H-[1,2,4]triazol-3-yl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-3-(2,2,2-trifluoro-ethyl)-urea (72 mg, 0.16 mmol) in EtOH (3 ml) was added KOH (10 mg, 0.18 mmol) and iodomethane (20 μl, 0.16 mmol) and the reaction mixture was stirred at room temperature overnight. The reaction mixture was placed in an ice bath and the precipitate formed filtered off. The precipitate was purified by reverse phase HPLC to afford the title compound (18 mg). MS: [M+H]+=462.

Provenance & Evidence