Nitromethane → HCID 59320904, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-Iodo-imidazo[1,2-a]pyridine-7-carbaldehyde (150 mg, 0.54 mmol) in THF (10 ml) was added nitromethane (88 μl, 1.63 mmol), diethylamine (6 μl, 0.05 mmol) and sieves (300 mg). The reaction mixture was heated at 55° C. for 2 hours before being cooled. The sieves were filtered off and the resulting solution partitioned between EtOAc and H2O. The organic layer was separated, dried (MgSO4), filtered and the solvent removed in vacuo to afford a crude product that was used as is (116 mg). MS: [M+H]+=334.

Provenance & Evidence