Methyl iodide → HCID 59321082, compound

Participants

Reaction Steps

1-[3-(7-Ethynyl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea (130 mg, 0.36 mmol) was dissolved in tert-butyl alcohol (2 mL) and water (2 mL). Sodium azide (24 mg, 0.36 mmol) was added, followed by iodomethane (0.18 mL of a 2M solution in THF, 0.36 mmol). The reaction was stirred at room temperature for 5 minutes before the addition of copper (II) sulphate (0.02 mL of a 1M aqueous solution, 0.02 mmol) and sodium ascorbate (7 mg, 0.04 mmol). The reaction was stirred for 2 h at room temperature.

Provenance & Evidence