1,2-Dichloroethane → 2-Imino-1(1-iodo-vinyl)-1,2-dihydro-pyridine-4-carboxylic acid N'-(2-fluoro-acetyl)-hydrazide

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Reaction Steps

To a solution of fluoroacetic acid (52 mg, 0.66 mmol) in CH2Cl2 (5 ml) was added EDC (127 mg, 0.66 mmol) and DMAP (5 mg, catalytic) and the reaction mixture stirred at room temperature for 15 min. 3-Iodo-imidazo[1,2-a]pyridine-7-carboxylic acid hydrazide (prepared as described in Example 329 steps a-c) (100 mg, 0.33 mmol) was added and the reaction mixture stirred at room temperature for 18 h. The reaction mixture was filtered, the precipitate washed with Et2O and dried to afford a crude product which was used directly in the next reaction (101 mg). MS: [M+H]+=363.

Provenance & Evidence