Sodium Hydroxide → HCID 131732099, compound

Participants

Reaction Steps

Hydroxylamine. HCl (30 mg, 0.43 mmol) was added to 3-{3-[3-(2,2,2-trifluoro-ethyl)-ureido]-phenyl}-imidazo[1,2-a]pyridine-7-carboxylic acid 1-dimethylamino-meth-(E)-ylideneamide (135 mg, 0.3 mmol) and 5N NaOH (75 μl, 0.38 mmol) in AcOH/H2O (7:3, 1 ml) at RT. The reaction mixture was stirred at room temperature for 2 h before being heated at 60° C. for 7 h. The reaction mixture was allowed to cool then the volatiles removed in vacuo. The residue was purified by preparative HPLC to afford the desired product (35 mg). MS: [M+H]+ 403.

Provenance & Evidence