Tetrabutylammonium Fluoride → HCID 59320886, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(2,2,2-Trifluoro-ethyl)-3-[3-(7-trimethylsilanylethynyl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-urea (25 mg, 0.06 mmol) in THF (5 ml) at 0° C. was added a 1M tetrabutylammonium fluoride solution (0.09 ml) and the reaction mixture stirred for 1 h at 0° C. The reaction mixture was diluted with water and extracted with CH2Cl2. The organic layer was washed with brine, dried (MgSO4) and the solvent removed in vacuo. The residue was purified by reverse phase HPLC to afford the product as an off-white solid (4.2 mg). MS: [M+H]+ 359

Provenance & Evidence