2-(3-Bromophenyl)-2-methyloxetane → HCID 59321116, compound

HRID 341252Notes

Reaction equation

HRID 341252 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]2([CH3:12])[CH2:11][CH2:10][O:9]2)[CH:5]=[CH:6][CH:7]=1.CC1(C)C(C)(C)OB([C:21]2[CH:26]=[CH:25][N:24]3[C:27]([C:30]4[CH:31]=[C:32]([NH:36][C:37]([NH:39][CH2:40][C:41]([F:44])([F:43])[F:42])=[O:38])[CH:33]=[CH:34][CH:35]=4)=[CH:28][N:29]=[C:23]3[CH:22]=2)O1>>[CH3:12][C:8]1([C:4]2[CH:3]=[C:2]([C:21]3[CH:26]=[CH:25][N:24]4[C:27]([C:30]5[CH:31]=[C:32]([NH:36][C:37]([NH:39][CH2:40][C:41]([F:42])([F:44])[F:43])=[O:38])[CH:33]=[CH:34][CH:35]=5)=[CH:28][N:29]=[C:23]4[CH:22]=3)[CH:7]=[CH:6][CH:5]=2)[CH2:11][CH2:10][O:9]1

Participants

3

Reactant 2

HCID 177498952-(3-Bromophenyl)-2-methyloxetaneHCID 59320805HCID 59320805, compound

Product 1

HCID 59321116HCID 59321116, compound

Procedure

2-(3-Bromophenyl)-2-methyloxetane may be coupled with 1-{3-[7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-3-(2,2,2-trifluoro-ethyl)-urea according to procedure E3.

Sources & evidence

ORD record
ord-569b8f587a1e43a5b6781725a8c0340b
Source dataset
uspto-grants-2014_11
Patent number
US08895745B2

Reaction notes

Loading…