HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 341257Generated: November 1, 2026
Hydrochloric Acid → 2-(2H-Benzotriazol-2-yl)-6-chloromethyl-4-methyl-phenol
https://huagongshe.com/reaction/341257
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Drometrizole | HCID 17113 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-(2H-Benzotriazol-2-yl)-6-chloromethyl-4-methyl-phenol | HCID 54751948 | 95% |
Reaction Steps
A mixture of 2-(2H-benzotriazol-2-yl)-4-methyl-phenol (100.0 g, 0.44 mol), paraformaldehyde (26.4 g, 0.88 mol), sulphuric acid (10.9 g, 110 mmol), conc. HCl (200 mL), and acetic acid (500 mL) is heated to 90° C. for six hours. The precipitated product is isolated by filtration and washed subsequently with AcOH, AcOH:heptane (1:1), and heptane and dried at 45° C. (95% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08895754B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-8bc348d0939c466f93dacaaeffa756d6 |
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| Source note | uspto-grants-2014_11 |
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