Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-{[5-(Methylsulfanyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 5-(Methylthio)thiazol-2-amine | HCID 351678 | — |
| 반응물 | 3-(Chlorocarbonyl)phenyl acetate | HCID 12998558 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-{[5-(Methylsulfanyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate | HCID 57571876 | 65% |
반응 단계
Following the procedure for the synthesis of example 85, intermediate 511 (0.815 g, 4.10 mmol) dissolved in dry THF (25.0 mL), triethylamine (0.572 mL, 4.10 mmol), and 512 (0.500 g, 3.42 mmol) dissolved in dry THF (10.0 mL) gave 77 (0.681 g, 65%) as a tan solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08895752B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-2805f66cb8354932ab7ef9fc5b493bb3 |
| 출처 메모 | uspto-grants-2014_11 |