HCID 70673730, compound → HCID 70673733, compound

Participants

Reaction Steps

A suspension of benzyl 4-nitro-3-(dimethyl-n-octylsilyl)butanoate (220 mg, 0.560 mmol) and palladium hydroxide (20% on carbon, wetted with ca. 50% water, 44 mg) in methanol (2 ml) was subjected to catalytic reduction under a hydrogen atmosphere [0.25 MPa (gauge pressure)] for 48 hours. After the suspension was filtered through Celite, and the solvent was evaporated, the residue was washed with water and recrystallized to obtain 4-amino-3-(dimethyl-n-octylsilyl)butanoic acid mentioned in the title.

Provenance & Evidence