4-Trimethylsilyl-3-cyanobutanoic acid → 4-Amino-3-[(trimethylsilyl)methyl]butanoic acid

Participants

Reaction Steps

A suspension of 4-(trimethylsilyl)-3-cyanobutanoic acid (178 mg, 0.962 mmol) and palladium hydroxide (20% on carbon, wetted with ca. 50% water, 36 mg) in methanol (10 ml) was subjected to catalytic reduction under a hydrogen atmosphere [0.45 MPa (gauge pressure)] for 48 hours. The reaction mixture was filtered through Celite, the solvent was evaporated, and then the residue was recrystallized to obtain 4-amino-3-(trimethylsilylmethyl)butanoic acid (172 mg, 95%) mentioned in the title as colorless fine prism crystals.

Provenance & Evidence