Water → HCID 86709902, compound

Participants

Reaction Steps

Diethyl 2-cyano-2-[(1-methyl-1-silacyclopentan-1-yl)methyl]succinate (1.943 g, 6.25 mmol) was treated with water and lithium bromide in dimethylformamide in the same manner as that of Example 15. The reaction mixture was treated in a conventional manner, and the residue was purified by silica gel column chromatography [hexane/ethyl acetate (14:1)] to obtain ethyl 4-(1-methyl-1-silacyclopentan-1-yl)-3-cyanobutanoate (1.321 g, 88%) mentioned in the title was obtained as colorless oil.

Provenance & Evidence