Lithium Hydroxide → HCID 86709904, compound

Participants

Reaction Steps

Ethyl 4-(1-methyl-1-silacyclopentan-1-yl)-3-cyanobutanoate (1.306 g, 5.46 mmol) was hydrolyzed with lithium hydroxide in the same manner as that of Example 16, and then the reaction mixture was treated in a conventional manner. The residue was purified by silica gel column chromatography (2% methanol/chloroform) to obtain 4-(1-methyl-1-silacyclopentan-1-yl)-3-cyanobutanoic acid (1.158 g, quant.) mentioned in the title as colorless oil.

Provenance & Evidence