Sodium Hydroxide → 4,6-Dichloro-7-(2,5-dihydropyrrol-1-yl-carbonyl)-quinazoline

HRID 34139Notes

Reaction equation

HRID 34139 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:13](Cl)=[O:14])=[C:9]([Cl:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH:16]1[CH2:20][CH2:19][CH:18]=[CH:17]1.[OH-].[Na+]>ClCCl>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:13]([N:16]3[CH2:20][CH:19]=[CH:18][CH2:17]3)=[O:14])=[C:9]([Cl:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 94395PyrrolineHCID 876267984,6-Dichloro-quinazoline-7-carboxylic acid chloride

Product 1

HCID 866326954,6-Dichloro-7-(2,5-dihydropyrrol-1-yl-carbonyl)-quinazoline

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared analogously to Example 2c from 4,6-dichloro-quinazoline-7-carboxylic acid chloride, pyrroline and sodium hydroxide solution in dichloromethane

Sources & evidence

ORD record
ord-57bd4cf925a74b5389a9a91520c2d445
Source dataset
uspto-grants-2008_09
Patent number
US07429597B2

Reaction notes

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