Hydrochloric Acid → HCID 66802769, compound

Participants

Reaction Steps

To tert-butyl N-[4-(3-{4-amino-6-[methyl(phenyl)amino]-1,3,5-triazin-2-yl}-1,2,4-oxadiazol-5-yl)cyclohexyl]carbamate (Example 423, 2.349 g, 5.035 mmol) was added hydrogen chloride solution (4M in 1,4-dioxane, 10 mL, 40 mmol) and the mixture was stirred at room temperature for 4 h. The mixture was concentrated under vacuum, water was added and the aqueous was neutralized to pH7 using saturated aq. sodium bicarbonate. The resultant precipitate was collected by filtration to afford the title compound as a white solid (0.877 g, 48%).

Provenance & Evidence