Isobutyric Acid → HCID 66803363, compound

Participants

Reaction Steps

To a solution of 2-methylpropanoic acid (0.03 g, 0.327 mmol) in DMF (5 mL) was added DIPEA (0.122 mL, 0.682 mmol) followed by (1H-benzotriazol-1-yloxy)[tris(dimethylamino)]phosphonium hexafluorophosphate (0.13 g, 0.3 mmol). The reaction mixture was stirred at room temperature for 5 min and 6-[5-(4-aminocyclohexyl)-1,2,4-oxadiazol-3-yl]-2-N-methyl-2-N-phenyl-1,3,5-triazine-2,4-diamine (batch 1 from Example 422, 0.1 g, 0.273 mmol) was added. The reaction mixture was stirred at room temperature for 16 h and then concentrated, extracted with EtOAc, washed with water, dried over sodium sulfate and concentrated. The residue was purified by FCC, eluting with 0-10% MeOH in DCM. The crude product was dissolved in EtOAc, washed with saturated aq. sodium bicarbonate, dried over sodium sulfate and concentrated under vacuum to afford the title compound (0.0255 g, 21%).

Provenance & Evidence