Phenol → HCID 66803014, compound

Participants

Reaction Steps

To a solution of 4-(3-{4-amino-6-[methyl(phenyl)amino]-1,3,5-triazin-2-yl}-1,2,4-oxadiazol-5-yl)cyclohexan-1-ol (Example 424, 0.1 g, 0.272 mmol) in THF (4 mL) was added phenol (0.03 g, 0.272 mmol), triphenylphosphine (0.09 g, 0.327 mmol) and N-{[(tert-butoxy)carbonyl]imino}(tert-butoxy)formamide (0.08 g, 0.327 mmol). The reaction mixture was stirred at room temperature 16 h. The mixture was then concentrated and purified by preparative HPLC, Method D, to afford the title compound (0.010 g, 8%).

Provenance & Evidence