Trifluoroacetic acid → N-Methyl-6-[5-(3-phenoxymethylazetidin-1-yl)-[1,2,4]oxadiazol-3-yl]-N-phenyl-[1,3,5]triazine-2,4-diamine

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Reaction Steps

3-Phenoxymethyl-azetidine-1-carboxylic acid tert-butyl ester (Intermediate 166, 50 mg, 0.189 mmol) was stirred in a mixture of DCM (1 mL) and trifluoroacetic acid (0.25 mL) at room temperature for 30 min. The mixture was evaporated under vacuum and the residue was dissolved in anhydrous DMF (0.5 mL). DIPEA (165 μL, 0.945 mmol) was added, followed by a solution of N-methyl-N-phenyl-6-(5-trichloromethyl-[1,2,4]oxadiazol-3-yl)-[1,3,5]triazine-2,4-diamine (prepared in an analogous manner to Intermediate 60, 37 mg, 0.095 mmol) in DMF (1.5 mL). The reaction was stirred at room temperature for approximately 42 h. The mixture was diluted with EtOAc (15 mL) then washed with saturated aq. ammonium chloride (3×5 mL), saturated aq. sodium carbonate (3×5 mL), brine (5 mL), dried over sodium sulfate and evaporated under vacuum. The crude residue was purified by flash chromatography (0-2% MeOH in DCM) and then further purified by preparative HPLC, Method D, to afford the title compound (6 mg, 7%).

Provenance & Evidence