Hydrochloric Acid → HCID 66802876, compound

Participants

Reaction Steps

To a stirred solution of 5-{3-[4-amino-6-(methyl-phenyl-amino)-[1,3,5]triazin-2-yl]-[1,2,4]oxadiazol-5-yl}-thiophene-2-carboxylic acid methyl ester (Example 82, 1.02 g, 2.45 mmol) in methanol (5 mL) was added aqueous sodium hydroxide solution (2M, 5 mL). The mixture was stirred for 18 h then acidified with hydrochloric acid (1M, 10 mL). The precipitate formed was filtered off and dried in vacuo at 50 C for 2 h to give the title compound (450 mg, 46%). Method B HPLC-MS: MH+ requires m/z=396. Found: m/z=396, Rt=1.84 min (68%).

Provenance & Evidence