Potassium Carbonate → HCID 66803180, compound

Participants

Reaction Steps

To a solution of 4-amino-6-phenylamino-[1,3,5]triazine-2-carbonitrile (prepared in an analogous manner to Intermediate 5, 160 mg, 0.75 mmol) in DMF (6 mL) was added potassium carbonate (207 mg, 150 μmol) followed by bromomethyl-cyclopropane (111 mg, 830 μmol). The mixture was heated at 120 C for 3 h, allowed to cool to room temperature before extracting into ethyl acetate (10 mL) and washing with water (3×10 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the title compound, which was used without further purification (300 mg, >100%). Method C HPLC-MS: MH+ requires m/z=267. Found: m/z=267, Rt=1.38 min (43%).

Provenance & Evidence