Hydrochloric Acid → HCID 86710520, compound

Participants

Reaction Steps

A 4N solution of HCl in dioxane (7 mL, 28.2 mmol) was added slowly to a solution of tert-butyl 3-(3-{4-amino-6-[methyl(phenyl)amino]-1,3,5-triazin-2-yl}-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboxylate (Intermediate 114, 1.24 g, 2.82 mmol) in dioxane (15 mL) at room temperature. The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was concentrated under vacuum to afford the title compound as a yellow solid (1.05 g, 100%). Method B HPLC-MS: MH+ (free-based) requires m/z=339 Found: m/z=339, Rt=1.20 min (96%).

Provenance & Evidence