HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-(methylsulfonyloxymethyl)piperidine-1-carboxylate → HCID 57898964, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-(methylsulfonyloxymethyl)piperidine-1-carboxylate | HCID 2765838 | — |
| Reactant | 1-Propanethiol, sodium salt (1:1) | HCID 4681725 | — |
| Reactant | HCID 86710527 | HCID 86710527 | — |
| Product | HCID 57898964 | HCID 57898964 | 60% |
Reaction Steps
tert-Butyl 4-[(propan-2-ylsulfanyl)methyl]piperidine-1-carboxylate was prepared from tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate (Intermediate 181, 0.320 g, 1.091 mmol) and sodium propanethiolate (0.161 g, 1.636 mmol) according to the method described for Intermediate 183 to afford the title compound (0.180 g, 60%). Method B HPLC-MS: MH+ requires m/z=274 Found: m/z=218 (M-tert-Bu), Rt=2.51 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895733B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-d8ff25f5156e4278983270ba225be002 |
| Source note | uspto-grants-2014_11 |