Sodium Hydroxide → HCID 25054206, compound

HRID 341539Notes

Reaction equation

HRID 341539 reaction equation
[F:1][C:2]([F:17])([F:16])[CH2:3][CH2:4][O:5][C:6]1[N:11]=[CH:10][C:9]([C:12]([O:14]C)=[O:13])=[CH:8][CH:7]=1.[OH-].[Na+]>CCO>[F:17][C:2]([F:1])([F:16])[CH2:3][CH2:4][O:5][C:6]1[N:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66802967HCID 66802967, compound2×

Product 1

HCID 25054206HCID 25054206, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 6-(3,3,3-trifluoropropoxy)pyridine-3-carboxylate (Intermediate 231, 0.240 g, 0.91 mmol) was dissolved in EtOH (7.5 mL) and 2M aq. sodium hydroxide (1.37 mL, 2.74 mmol) was added. The mixture was stirred at room temperature for 3 h. The mixture was then concentrated to a minimum volume and acidified by adding 2M hydrochloric acid.

Workup

  1. concentrationThe mixture was then concentrated to a minimum volume
  2. additionby adding 2M hydrochloric acid

Sources & evidence

ORD record
ord-0c26aab1e82142eaa38f32e4ce3ce84d
Source dataset
uspto-grants-2014_11
Patent number
US08895733B2

Reaction notes

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