HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethylcyclopropane → 6-[(Cyclopropylmethyl)sulfanyl]pyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | 6-sulfanylpyridine-3-carboxylic acid | HCID 178524518 | — |
| Product | 6-[(Cyclopropylmethyl)sulfanyl]pyridine-3-carboxylic acid | HCID 61305096 | 77.3% |
Reaction Steps
6-[(Cyclopropylmethyl)sulfanyl]pyridine-3-carboxylic acid was prepared from 6-sulfanylpyridine-3-carboxylic acid (0.5 g, 3.22 mmol) and (bromomethyl)cyclopropane (0.44 g, 3.22 mmol) according to the method described for Intermediate 276 to afford the title compound (0.521 g, 61%). Method B HPLC-MS: MH+ requires m/z=210 Found: m/z=210, Rt=1.77 min (79%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895733B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-be2142de39f84b53b4c7f29d0edc9167 |
| Source note | uspto-grants-2014_11 |