Potassium Carbonate → 5-Heptyloxy-2-[4-(5-(2-(2-(tetrafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)pentyloxy)phenyl]pyrimidine

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Reaction Steps

Using essentially the procedure of Comparative Example A, the title compound was prepared by combining 5-(2-(2-(tetrafluoroethoxy)tetrafluoroethoxy)-2,2 -difluoroethoxy)-1-bromopentane (7.2 g, 15.0 mmol), 5 -heptyloxy-2-(4-hydroxyphenyl)pyrimidine (3 g, 11.0 mmol), potassium carbonate (1.6 g, 12.7 mmol), and acetonitrile (50 mL). The resulting crude product was isolated and purified essentially as in Comparative Example A to yield 4.95 g.

Provenance & Evidence