Potassium Carbonate → 5-Heptyloxy-2-[4-(3-(2-(2-(tetrafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propyloxy)phenyl]pyrimidine

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Reaction Steps

Using essentially the procedure of Comparative Example A, the title compound was prepared by combining 3-(2-(2-(tetrafluoroethoxy)tetrafluoroethoxy)-2,2 -difluoroethoxy)-l-bromopropane (5.1 g, 38.5 mmol), 5 -heptyloxy-2-(4-hydroxyphenyl)pyrimidine (3 g, 11.0 mmol), potassium carbonate (1.6 g, 12.7 mmol), and acetonitrile (58 mL). The resulting crude product was isolated and purified essentially as in Comparative Example A to yield 5.1 g.

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