Trimethylsilyl iodide → HCID 178511093, compound

HRID 34173Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([N:14]1[CH2:18][CH:17]=[CH:16][CH2:15]1)=[O:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:19][C@H:20]([C:34]1[NH:38][C:37]2[CH:39]=[CH:40][C:41]([Cl:43])=[CH:42][C:36]=2[N:35]=1)[CH2:21][CH2:22][NH:23]C(OCC1C=CC=CC=1)=O.C[Si](I)(C)C>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([N:14]1[CH2:18][CH:17]=[CH:16][CH2:15]1)=[O:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:19][C@H:20]([C:34]1[NH:38][C:37]2[CH:39]=[CH:40][C:41]([Cl:43])=[CH:42][C:36]=2[N:35]=1)[CH2:21][CH2:22][NH2:23]

Participants

Reactant 2

HCID 85247Trimethylsilyl iodide

HCID 178523355HCID 178523355, compound

Product 1

HCID 178511093HCID 178511093, compound

Procedure

Prepared analogously to Example 15c from 6-chloro-4-[(1S)-3-(benzyloxycarbonyl-amino)-1-(5-chloro-1H-benzimidazol-2-yl)-propyl-amino]-7-(2,5-dihydropyrrol-1-yl-carbonyl)-quinazoline and trimethylsilyl iodide.

Sources & evidence

ORD record: ord-eb0814db1a4d41ddabf7cdf757c0ee93
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07429597B2

Reaction notes

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