Trimethylsilyl iodide → HCID 178525469, compound

HRID 34174Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:19][C@H:20]([C:33]1[NH:37][C:36]2[CH:38]=[CH:39][C:40]([Cl:42])=[CH:41][C:35]=2[N:34]=1)[CH2:21][CH2:22][C:23]([O:25]CC1C=CC=CC=1)=[O:24].C[Si](I)(C)C>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:19][C@H:20]([C:33]1[NH:37][C:36]2[CH:38]=[CH:39][C:40]([Cl:42])=[CH:41][C:35]=2[N:34]=1)[CH2:21][CH2:22][C:23]([OH:25])=[O:24]

Participants

Reactant 2

HCID 85247Trimethylsilyl iodide

HCID 178520642HCID 178520642, compound

Product 1

HCID 178525469HCID 178525469, compound

Procedure

Prepared analogously to Example 15c from 6-chloro-4-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-benzyloxycarbonyl-propylamino]-7-(pyrrolidin-1-yl-carbonyl)-quinazoline and trimethylsilyl iodide.

Sources & evidence

ORD record: ord-71c8edf1f8d84914b6ed312c1c0f1c2a
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07429597B2

Reaction notes

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