反应详情

A solution of 15.4 g of 3,3-dimethyl-4-phenylazetidin-2-one and 14.3 g of chlorotrimethylsilane in 150 cm3 of anhydrous methanol are refluxed for 6 hours. The solution is then evaporated and ethyl acetate and aqueous sodium bicarbonate at 5% are added. The organic phase is washed with water, is dried on sodium sulphate, and is then evaporated, obtaining 17.8 g of methyl 3-phenyl-3-amino-2,2-dimethylpropanoate (yield 98%).

1. customThe solution is then evaporated
2. additionethyl acetate and aqueous sodium bicarbonate at 5% are added
3. washThe organic phase is washed with water
4. customis dried on sodium sulphate
5. customis then evaporated