反应详情

A solution of 10 g of 4-phenylazetidin-2-one and 15.2 g of chlorotrimethylsilane in 150 cm3 of anhydrous tert.-butanol are refluxed for 7 days. The solution is then evaporated and ethyl acetate and aqueous sodium bicarbonate at 5% are added. The organic phase is washed with water, dried on sodium sulphate and is then evaporated. 7 g of tert.- butyl 3-phenyl-3-amino-propanoate are obtained (yield 47%).

1. customThe solution is then evaporated
2. additionethyl acetate and aqueous sodium bicarbonate at 5% are added
3. washThe organic phase is washed with water
4. customdried on sodium sulphate
5. customis then evaporated