Water → [(5-(3-Bromopropyl)-2-pyridinyl)aminomethylene]bis[phosphonic acid] tetraethyl ester

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Reaction Steps

A mixture of [(5-(3-hydroxypropyl)-2-pyridinyl)aminomethylene]-bis(phosphonic acid] tetraethyl ester (10 mmol), carbon tetrabromide (11 mmol) and triphenyl phosphine (11 mmol) in dichloromethane (100 ml) is stirred at room temperature for 5 h. Water is added and the product is extracted with dichloromethane. The combined organic extracts are dried and concentrated. The residue is purified by flash column chromatography to give [(5-(3-bromopropyl)-2-pyridinyl)aminomethylene]bis[phosphonic acid] tetraethyl ester.

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