HCID 23700354, compound → HCID 54016127, compound

Participants

Reaction Conditions

Reaction Steps

A solution of [5-bromo-2-(3-pyridinyl)pentylidene]bis [phosphonic acid] diethyl ester (5.0 mmol) is stirred in dry acetone (35 ml) and sodium thioacetate (5.2 mmol) is added. The mixture is stirred at 50° C. for 12 hours. After cooling to room temperature the solvent is removed under reduced pressure. The crude residue is dissolved in methylene chloride and washed with water. The organic layer is then dried and concentrated under reduced pressure. The desired product is purified by flash chromatography using a 5-10% isopropanol in methylene chloride gradient on silica gel.

Provenance & Evidence