HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178463494, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Tert-butyl 1,4-diazepane-1-carboxylate | HCID 2756058 | — |
| Reactant | Pentafluorphenol-tetramethyluronium hexafluorophosphat | HCID 15840204 | — |
| Reactant | 6-chloro-4-(1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline | HCID 178463504 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 178463494 | HCID 178463494 | — |
Reaction Steps
Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and 1-tert.-butyloxycarbonyl-[1,4]diazepan in DMSO at ambient temperature and subsequent treatment with trifluoroacetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429597B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-a4a2a4eb26774a6d87b18d17724bb7d1 |
| Source note | uspto-grants-2008_09 |