反应详情

温度

60 °C

To 2.04 g of a 5% palladium-carbon catalyst, 15 ml of water containing 10.2 g of potassium acetate was added. Then, a solution of 10.18 g (21.6 mmol) of 4-chloro-6-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]-2-(nitrophenyl)quinoline obtained in Example 4 dissolved in 30 ml of ethyl acetate and 240 ml of ethanol at 70° C. was added thereto, and the thus-prepared mixture was stirred under a hydrogen atmosphere at 60° C. for 3 hours. After adding 150 ml of chloroform and 200 ml of water thereto, the thus-prepared mixture was filtered through celite. The resulting filtrate was separated out, and the organic layer obtained was concentrated to 95.0 g in an evaporator. After allowing to stand at 0° C., the crystals precipitated were collected by filtration. The resulting filtration residue was washed with 10 ml of ethanol three times and dried under reduced pressure at 40° C. to obtain 6.70 g of 2-{6-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]quinolin-2-yl}aniline.

1. filtrationthe thus-prepared mixture was filtered through celite
2. customThe resulting filtrate was separated out
3. customthe organic layer obtained
4. concentrationwas concentrated to 95.0 g in an evaporator
5. customto stand at 0° C.
6. customthe crystals precipitated
7. filtrationwere collected by filtration
8. filtrationThe resulting filtration residue
9. washwas washed with 10 ml of ethanol three times
10. customdried under reduced pressure at 40° C.