5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-ol → 5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-ol hydrochloride

HRID 341829Notes

Reaction equation

HRID 341829 reaction equation
[C:1]1([CH2:7][CH2:8][C:9]2[N:19]3[C:20]4[C:15]([CH:16]([OH:21])[CH2:17][CH2:18]3)=[CH:14][CH:13]=[CH:12][C:11]=4[N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:22].CO>CCOCC.ClCCl>[ClH:22].[C:1]1([CH2:7][CH2:8][C:9]2[N:19]3[C:20]4[C:15]([CH:16]([OH:21])[CH2:17][CH2:18]3)=[CH:14][CH:13]=[CH:12][C:11]=4[N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 98604535,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-olHCID 21893726Hydrochloride methanol

Product 1

HCID 675964275,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-ol hydrochloride

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

A portion (0.2 g) of 5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-ol obtained in Example 4 was dissolved in ether (10 mL) and dichloromethane (10 mL); following the addition of 10% HCl-methanol solution (0.5 g), the solvents were removed under reduced pressure, followed by crystallization from ether; upon filtration, the titled compound was obtained as colorless crystals (0.23 g).

Workup

  1. customthe solvents were removed under reduced pressure
  2. customfollowed by crystallization from ether
  3. filtrationupon filtration

Sources & evidence

ORD record
ord-13d96a448e5a4c50ba187adf97220eb7
Source dataset
uspto-grants-1999_01
Patent number
US05856334

Reaction notes

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