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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 34184Generated: October 31, 2026

4-Methylpiperidine → HCID 178428613, compound

https://huagongshe.com/reaction/34184

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethylpiperidineHCID 69381—
ReactantDiisopropylethylamineHCID 81531—
ReactantPentafluorphenol-tetramethyluronium hexafluorophosphatHCID 15840204—
Reactant6-chloro-4-(1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazolineHCID 178463504—
SolventDimethyl SulfoxideHCID 679—
ProductHCID 178428613HCID 178428613—

Reaction Steps

Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and 4-methyl-piperidine in DMSO at ambient temperature.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07429597B2
Source datasetuspto-grants-2008_09
ORD IDord-0804a2f83452400ab389dd30238e0130
Source noteuspto-grants-2008_09