反应详情

In 35 ml of acetone was dissolved 2.7 g (10 mmol) of N-[3-(dimethylamino)]propyl-N'-(3-morpholino)propyl -thiourea (Compound (1)). Further, 4.2 g (20 mmol) of mercury oxide was added, and the resulting mixture was stirred for 2 hours under reflux. Then, the reaction mixture was allowed to cool and filtered. The solvent was distilled off to obtain a crude product. This product was evaporated under reduced pressure to obtain 1.5 g (yield: 60%) of N-[3-(dimethyl-amino)]propyl-N'-(3-morpholino)propyl-carbodiimide (Compound (2) in the following reaction formula (1)). Its boiling point (b.p.) was from 125° to 128° C./0.2 mmHg. NMR spectrum data of Compound (2) are shown below.

1. temperatureunder reflux
2. temperatureto cool
3. filtrationfiltered
4. distillationThe solvent was distilled off
5. customto obtain a crude product
6. customThis product was evaporated under reduced pressure