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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 34192Generated: October 26, 2026

2-Methylpiperidine → HCID 178463466, compound

https://huagongshe.com/reaction/34192

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-MethylpiperidineHCID 7974—
ReactantDiisopropylethylamineHCID 81531—
ReactantPentafluorphenol-tetramethyluronium hexafluorophosphatHCID 15840204—
Reactant6-chloro-4-(1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazolineHCID 178463504—
SolventDimethyl SulfoxideHCID 679—
ProductHCID 178463466HCID 178463466—

Reaction Steps

Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and 2-methyl-piperidine in DMSO at ambient temperature.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07429597B2
Source datasetuspto-grants-2008_09
ORD IDord-e47277f835f84108893792a041f7fc92
Source noteuspto-grants-2008_09