2'-O-Nonylcytidine → 4-Benzoyl-2'-O-nonylcytidine

HRID 341935Notes

Reaction equation

HRID 341935 reaction equation
[CH2:1]([O:10][C@@H:11]1[C@H:15]([OH:16])[C@@H:14]([CH2:17][OH:18])[O:13][C@H:12]1[N:19]1[CH:26]=[CH:25][C:23]([NH2:24])=[N:22][C:20]1=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[CH2:27]([O:36][C@@H]1[C@@H](CO)O[C@@H](N2C=CC(N)=NC2=O)[C@@H]1O)[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]CC.C(NC1C=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2OCCCCCCCCC)C(=O)N=1)(=O)C1C=CC=CC=1>>[C:27]([C:23]1([NH2:24])[CH:25]=[CH:26][N:19]([C@@H:12]2[O:13][C@H:14]([CH2:17][OH:18])[C@@H:15]([OH:16])[C@H:11]2[O:10][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[C:20](=[O:21])[NH:22]1)(=[O:36])[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

4

Reactant 3

HCID 228683932'-O-NonylcytidineHCID 228747483'-O-nonylcytidineHCID 22874773HCID 22874773, compound

Product 1

HCID 675920904-Benzoyl-2'-O-nonylcytidine

Procedure

The mixture of 2'-O-nonylcytidine and 3'-O-nonylcytidine (11.5 g) is converted to N4-benzoyl-2'-O-nonylcytidine as per the procedure of Example 71, Step 2.

Sources & evidence

ORD record
ord-ecfc0e5f9bf8440bbacb2b3ada817ed1
Source dataset
uspto-grants-1999_01
Patent number
US05856466

Reaction notes

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