HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178464169, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | tert-Butyl 3-(ethylamino)propylcarbamate | HCID 15370795 | — |
| Reactant | Pentafluorphenol-tetramethyluronium hexafluorophosphat | HCID 15840204 | — |
| Reactant | 6-chloro-4-(1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline | HCID 178463504 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 178464169 | HCID 178464169 | — |
Reaction Steps
Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and N-(3-tert.-butyloxycarbonylamino-propyl)-ethylamine in DMSO at ambient temperature and subsequent treatment with trifluoroacetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429597B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-62fd84d78c70432480263a023662162e |
| Source note | uspto-grants-2008_09 |