HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → beta-Methyl-alpha-phenyl-1-pyrrolidineethanol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 1-Phenyl-2-(pyrrolidin-1-yl)propan-1-ol | HCID 4079506 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | beta-Methyl-alpha-phenyl-1-pyrrolidineethanol hydrochloride | HCID 53395958 | — |
Reaction Steps
adding a solution of hydrogen chloride in isopropanol to a toluene solution of [R-(R*,S*)]-β-methyl-α-phenyl-1-pyrrolidineethanol or its enantiomer at about 10° to about 15° C. and maintaining a reaction temperature of about 10° to about 25° C. to form [R-(R*,S*)]-β-methyl-α-phenyl-1-pyrrolidineethanol hydrochloride or its enantiomer;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05856492 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-291ec677f243435d9c65ff0f059cfb75 |
| Source note | uspto-grants-1999_01 |