反应详情

In a 300 ml four-necked flask equipped with a stirrer, a thermometer, and a condenser, 100 g of monochlorobenzene was placed in advance, to which 33.4 g (0.2 mol) of 2-(methylthio)benzaldehyde oxime was added under nitrogen atmosphere. 25.2 g (0.21 mol) Of thionyl chloride was added dropwise thereto while stirring at a temperature of from -10° to -15° C. and allowed to react for 1 hour at the same temperature. After the termination of the reaction, 15.6 g (0.22 mol) of chlorine was continuously blown into the reaction mixture while stirring at a temperature of from 70° to 80° C. and allowed to react for 1 hour at the same temperature. After the termination of the reaction, the solvent was distilled off to give 33.1 g of 3-chloro-1,2-benzisothiazole.

1. customIn a 300 ml four-necked flask equipped with a stirrer
2. additionwas added under nitrogen atmosphere
3. customto react for 1 hour at the same temperature
4. stirringwhile stirring at a temperature of from 70° to 80° C.
5. customto react for 1 hour at the same temperature
6. customAfter the termination of the reaction
7. distillationthe solvent was distilled off