HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-((3-(2-Acetylphenyl)-1-(3-((2-tetrahydropyranyloxy)methyl)phenyl)propyl)thio)-2-methylpropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 54537147 | HCID 54537147 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | 3-((3-(2-Acetylphenyl)-1-(3-((2-tetrahydropyranyloxy)methyl)phenyl)propyl)thio)-2-methylpropanoic acid | HCID 53884964 | — |
Reaction Steps
A mixture of the ester of Step 7 (6.67 mmol) and 1.0N NaOH (13 mL) in 55 mL of MeOH:THF 3:2 was stirred at r.t. for 24 hours. 25% Aq NH4OAc was then added and the mixture was acidified with HOAC. The title acid was extracted with EtOAc, dried over Na2SO4 and purified by flash chromatography on silica with acetone:toluene:HOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05856322 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-a33b053c8a2b48f0add51d281ca69c20 |
| Source note | uspto-grants-1999_01 |