反应详情

3-(2-Pyrrolidinylethyl)-1-(p-toluenesulfonyl)-5-(triethylsilylethynyl)-indole (Example 6a, 130 mg, 0.26 mmol) was mixed with 5% potassium hydroxide in methanol (20 mL) and stirred at reflux for up to 48 h. The solvent was evaporated to about 4 mL, poured into dichloromethane (40 mL), washed with brine (40 mL), dried over sodium sulfate and evaporated. Chromatography on silica gel (dichloromethane/methanol/ammonium hydroxide 50:7:1) gave the title compound as a yellow oil (41 mg, 66%). HRMS-FAB+ for C16H19N2 : calculated MH+ : 239.15483, found MH+ : 239.15766.

1. temperatureat reflux for up to 48 h
2. customThe solvent was evaporated to about 4 mL
3. additionpoured into dichloromethane (40 mL)
4. washwashed with brine (40 mL)
5. dry with materialdried over sodium sulfate
6. customevaporated