HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 3,3,6,6-Tetramethyl-1,4-dioxane-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | M-Xylene | HCID 7929 | — |
| Reactant | 2-Hydroxyisobutyric acid | HCID 11671 | — |
| Product | 3,3,6,6-Tetramethyl-1,4-dioxane-2,5-dione | HCID 81211 | — |
Reaction Steps
Crude tetramethyl glycolide was prepared by direct liquid phase synthesis from 2-hydroxy-2-methylpropionic acid using m-xylene as the solvent and p-toluene sulfonic acid as the catalyst. The mixture was refluxed using a Dean-Stark tube to remove water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05856523 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-bf9317ff7c7f414d8e51bf749836759e |
| Source note | uspto-grants-1999_01 |